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Celiac disease

Celiac Disease: What It Is, Symptoms and How It's Diagnosed

A complete guide to celiac disease: causes, the most common symptoms in adults and children, the diagnostic path, and what to do after diagnosis.

DER

Dott.ssa Elena Rossi

Nutritionist & biologist

2 June 2026 2 min read
Table of contents

Key takeaways

  • Celiac disease is an autoimmune condition triggered by gluten, not a food allergy or intolerance.
  • Diagnosis requires blood tests and a duodenal biopsy: don't remove gluten from your diet before completing them.
  • The only treatment is a lifelong gluten-free diet, which allows symptoms to go into remission.
  • Screening is recommended for first-degree relatives too, given the genetic component of the disease.

What is celiac disease

Celiac disease is an autoimmune condition triggered by ingesting gluten, the protein found in wheat, barley and rye. In genetically predisposed people, gluten triggers an immune response that damages the intestinal villi, impairing nutrient absorption.

The most common symptoms

Symptoms vary widely from person to person and can appear at any age.

Gastrointestinal symptoms

Bloating, abdominal pain, alternating diarrhea and constipation, and nausea are the most frequent signs, especially in children.

Extraintestinal symptoms

Chronic fatigue, iron-deficiency anemia, dermatitis herpetiformis, recurring mouth ulcers and early osteoporosis are typical in adults.

How diagnosis works

Diagnosis is based on blood tests for anti-transglutaminase antibodies, followed by an endoscopy with duodenal biopsy to confirm damage to the intestinal villi. It's essential not to remove gluten from the diet before completing all tests.

After diagnosis: the gluten-free diet

The only effective treatment available today is a strictly gluten-free diet for life. Over time the intestinal lining regenerates and symptoms subside. Relying on AIC-certified venues and products helps avoid cross-contamination in everyday life.

DER

Dott.ssa Elena Rossi

Nutritionist & biologist

Nutritionist and biologist specializing in food intolerances, writing evidence-based guides for Mappa Senza Glutine on celiac disease, nutrition and health.

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Frequently asked questions

No, there is no definitive cure: management consists of strictly following a gluten-free diet for life.

Symptoms generally improve within a few weeks of removing gluten, while the intestinal lining can take months or years to fully regenerate.

Yes, celiac disease has a genetic component: screening is recommended for first-degree relatives even without obvious symptoms.

Looking for a safe place near you?

Discover our directory of certified restaurants, shops and hotels for an easier gluten-free life.

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Comments (2)

S

Sara V. 2 June 2026

Very clear article, it helped me a lot right after my diagnosis. Thank you!

P

Paolo N. 2 June 2026

Extremely useful, sharing it in the support group I follow.